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The can- [Telomerase and cancer]. [Article in Japanese] Oshimura M(1). Author information: (1)Department of Molecular & Cell Genetics, School of Life Sciences, Tottori University. Telomeres progressively shorten with age in somatic cells in culture and in vivo because DNA replication results the loss of sequence at the 5' ends of double-stranded DNA. Telomerase, a eukaryotic ribonucleoprotein (RNP) complex (26– 33), helps to stabilize telomere length in human stem cells, reproductive cells and cancer cells (35, 36) by adding TTAGGG repeats onto the telomeres using its intrinsic RNA as a template for reverse transcription .

Inhibiting telomerase caused tumor cell death but also led to alternative lengthening of telomeres (ALT) independent of telomerase. In this model, telomerase activation occurs after the selection of mutations that stimulate abnormal cell proliferation, and, thus, telomerase activation may be a relatively late event in tumor initiation that allows for genome stability after the acquisition of cancer-associated mutations. It is believed that cancer occurs because a genetic mutation can trigger the production of an enzyme, known as telomerase, which prevents telomeres from shortening. While every cell in the body has the genetic coding to produce telomerase, only certain cells actually need it. Telomerase has been a prime target for the development of effective therapeutics against cancer as it is expressed in the majority of cancer types as well as in cancer stem or stem-like cells.

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Köp Telomerases, Telomeres and Cancer av Guido Krupp, Reza Parwaresch på Bokus.com. 5. Telomerase and Radiosensiticity of Human Tumors; T.K. Pandita.

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It shows a survival advantage for short-telomere mice in a model of Myc-induced lymphoma, according to Feldser et al.

Studies in lower eukaryotes sug- gested that inactivation of human telomerase might be an effective cancer treatment. An unusual enzyme called telomerase acts on parts of chromosomes known as telomeres. The enzyme has recently been found in many human tumors and is being eyed as a new target for cancer therapy Longer telomeres will afford cancer cells additional divisions during which mutations can creep into the genetic code, including mutations that activate telomerase.
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Thus, telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors. Several pathways that regulate telomere length have been identified, and genome-scale studies have helped in mapping genes that are involved in telomere length control. Additionally, the nature of telomerase regulation is currently only poorly understood. More work on the tumor specific regulation of telomerase activity might provide either more opportunities for telomerase inhibition, or more skepticism, as a tumor cell might possess mechanisms for upregulating telomerase activity in the presence of inhibitors.

2021-04-14 · Telomerase is an important drug target for cancer. It is expressed in most tumours from virtually all types of cancers and is required for long-term maintenance of telomeres, which in turn is Pris: 2919 kr. Inbunden, 2003. Skickas inom 10-15 vardagar. Köp Telomerases, Telomeres and Cancer av Guido Krupp, Reza Parwaresch på Bokus.com. 5. Telomerase and Radiosensiticity of Human Tumors; T.K. Pandita.
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2 dec. 2019 — Ändarna av kromosomerna utgörs av en specifik repetitiv DNA-sekvens som kallas för telomerer vilka är viktiga vid cancerutveckling. Sofia Cancer Epidemiol Biomarkers Prev, 9 dec. 37. Verde, Z. m.

Telomerase has been a prime target for the development of effective therapeutics against cancer as it is expressed in the majority of cancer types as well as in cancer stem or stem-like cells. In addition, normal human cells including stem cells have lower telomerase activity and generally maintain telomeres at longer lengths compared to cancer [Telomerase and cancer]. [Article in Japanese] Oshimura M(1). Author information: (1)Department of Molecular & Cell Genetics, School of Life Sciences, Tottori University.
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Shortened telomere length is associated with increased risk of

A video overview of what telomerase is, its function in normal cells and how telomerase activating mutations can lead to cancer.By The Immortal Instruments: 2019-06-21 · The potential of telomerase gene therapy has long been debated amid cancer concerns, but this experiment suggests that those concerns are unfounded. There is no doubt that telomerase can and does regenerate tissue when it is delivered via gene therapy and that it does reverse various aspects of aging in multiple models. The knowledge of the basic biology of telomeres and telomerase has yielded fundamental insights into both cancer prevention and cancer promotion. The powerful and complex impact of telomere dynamics in model organisms and humans reflects the crucial role of telomere function in processes of genomic instability, organ homeostasis, chronic diseases, aging, and tumorigenesis. Telomerase therapy is not only unlikely to result in an increased risk of cancer but is likely to lower the risk of cancer compared to age-matched patients not treated with telomerase therapy. Review of available data suggests that cancer should not be considered a significant risk to patients undergoing telomerase therapy, but the actual outcome will require human trials.